Proton-sensing receptor GPR132 facilitates migration of astrocytes

Astrocytes are one of the first responders to central nervous system (CNS) injuries such as spinal cord injury (SCI). They thought repress injury-induced CNS inflammation well inhibit axonal regeneration. While reactive astrocytes migrate and accumulate around lesion core, mechanism astrocyte migration towards site remains unclear. Here, we examined possible involvement acidification expression proton-sensing receptors in migration, both mice models vitro. We found that several was increased at after SCI. Among these receptors, Gpr132 expressed primary cultured exhibited significant enhanced acidic conditions Furthermore, motility media by activation. These results suggest facilitates via receptor Gpr132.